Guides
Clinician-reviewed guides to Spravato, ketamine therapy and TMS: what to expect, how prior authorization works, side effects, maintenance schedules, Medicare and Medicaid rules, and how to compare treatments. Each guide lists a reviewer and a reviewed date.
Key facts
- 15 guides listed on this page.
Last reviewed Sep 1, 2026
Treatment guides
- At-home ketamine vs in-clinic treatment
How telehealth ketamine programs work, how they compare with infusions and Spravato on evidence, safety, cost and coverage, and questions to ask.
Reviewed Sep 1, 2026
- Driving and monitoring rules for Spravato and ketamine
What the REMS requires, why you cannot drive after treatment, how long observation lasts, and what to arrange before each visit.
Reviewed Sep 1, 2026
- How prior authorization works for Spravato
Step by step: what the clinic submits, what the plan checks, how long it takes, why requests get denied, and how to fix a denial.
Reviewed Sep 1, 2026
- Ketamine-assisted psychotherapy explained
How KAP combines low-dose ketamine with therapy, what a course looks like, how it differs from infusion clinics, and what insurance may cover.
Reviewed Sep 1, 2026
- Ketamine therapy: the complete guide
How IV, IM and oral ketamine are used for depression, who it helps, what a series looks like, why insurance rarely pays, and what it costs.
Reviewed Sep 1, 2026
- Maintenance schedules: keeping the response
How often Spravato, ketamine and TMS are continued after the initial course, what insurers reauthorize, and how tapering works.
Reviewed Sep 1, 2026
- Medicaid coverage for Spravato, ketamine and TMS: state by state overview
How state Medicaid programs and their managed care plans decide on Spravato and TMS, why ketamine infusions are excluded, and how to read your state's page.
Reviewed Sep 1, 2026
- Medicare and Spravato: what Part B pays and what you owe
How Original Medicare and Medicare Advantage cover Spravato, the billing codes involved, the 20 percent coinsurance, and the Medigap question.
Reviewed Sep 1, 2026
- Questions to ask a Spravato, ketamine or TMS clinic
The questions that separate a well-run clinic from a marketing operation, organized by topic, with the answers you should expect to hear.
Reviewed Sep 1, 2026
- Side effects and safety: Spravato, ketamine and TMS
The common, the uncommon and the serious side effects of each treatment, who should not have them, and what clinics monitor.
Reviewed Sep 1, 2026
- Spravato: the complete guide
What Spravato is, who qualifies, what a session is like, how insurance approves it, what it costs, and what the evidence shows.
Reviewed Sep 1, 2026
- TMS: the complete guide
How transcranial magnetic stimulation treats depression, who qualifies under insurance, what six weeks of daily sessions involve, and what it costs.
Reviewed Sep 1, 2026
- Treatment-resistant depression: what the criteria actually mean
The definition insurers use, what counts as an adequate antidepressant trial, how to document your history, and why the details decide approval.
Reviewed Sep 1, 2026
- What to expect at your first ketamine infusion
How a 40-minute infusion visit runs, what you feel, safety checks, and how to get the most from the session.
Reviewed Sep 1, 2026
- What to expect at your first Spravato session
Timeline of the first visit hour by hour, what you feel, what the clinic monitors, and how to prepare.
Reviewed Sep 1, 2026
By condition
- Ketamine therapy for anxiety
What the evidence shows for ketamine in anxiety disorders, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for anxiety
When Spravato is used for anxiety disorders, what the label and insurers allow, what to expect, and what it costs.
Reviewed Sep 1, 2026
- TMS for anxiety
Where TMS stands for anxiety disorders, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
- Ketamine therapy for bipolar depression
What the evidence shows for ketamine in the depressive phase of bipolar disorder, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for bipolar depression
When Spravato is used for the depressive phase of bipolar disorder, what the label and insurers allow, what to expect, and what it costs.
Reviewed Sep 1, 2026
- TMS for bipolar depression
Where TMS stands for the depressive phase of bipolar disorder, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
- Ketamine therapy for depression
What the evidence shows for ketamine in major depression, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for depression
When Spravato is used for major depression, what the criteria are, what response rates look like, and how it fits with antidepressants and therapy.
Reviewed Sep 1, 2026
- TMS for depression
Where TMS stands for major depression, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
- Ketamine therapy for OCD
What the evidence shows for ketamine in obsessive-compulsive disorder, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for OCD
When Spravato is used for obsessive-compulsive disorder, what the label and insurers allow, what to expect, and what it costs.
Reviewed Sep 1, 2026
- TMS for OCD
Where TMS stands for obsessive-compulsive disorder, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
- Ketamine therapy for PTSD
What the evidence shows for ketamine in post-traumatic stress disorder, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for PTSD
When Spravato is used for post-traumatic stress disorder, what the label and insurers allow, what to expect, and what it costs.
Reviewed Sep 1, 2026
- TMS for PTSD
Where TMS stands for post-traumatic stress disorder, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
- Ketamine therapy for treatment-resistant depression
What the evidence shows for ketamine in treatment-resistant depression, who is a candidate, what a course looks like, and why it is usually cash pay.
Reviewed Sep 1, 2026
- Spravato for treatment-resistant depression
When Spravato is used for treatment-resistant depression, what the label and insurers allow, what to expect, and what it costs.
Reviewed Sep 1, 2026
- TMS for treatment-resistant depression
Where TMS stands for treatment-resistant depression, FDA clearance and insurance status, what a course involves, and cost.
Reviewed Sep 1, 2026
Comparisons
- IV ketamine vs at-home ketamine
Infusions in a clinic and lozenges at home use the same drug with very different dosing precision, monitoring, evidence and cost.
Reviewed Sep 1, 2026
- Ketamine vs esketamine: the difference in one page
Esketamine is one half of the ketamine molecule, FDA approved as Spravato. What changes in effect, dosing, evidence, cost and coverage.
Reviewed Sep 1, 2026
- Spravato vs ketamine: which is right for you?
The practical differences between esketamine nasal spray and IV or IM ketamine: approval, coverage, cost, schedule, and evidence.
Reviewed Sep 1, 2026
- Spravato vs TMS: how to choose
Both are FDA approved and insured for treatment-resistant depression. They differ in schedule, side effects, who qualifies, and what maintenance looks like.
Reviewed Sep 1, 2026
- TMS vs ECT: what each is for
TMS is an office procedure with mild side effects; ECT is a hospital procedure under anesthesia with the highest remission rates for severe depression. When each is the right tool.
Reviewed Sep 1, 2026